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| Comparison of a physiognomy of a male who began treatment late at the age 9 1/2 (Before), and his condition at the age 10 1/2 (After). |
7 years old |
8 years old |
9 years old |
10 years old |
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The pictures show the transformation from an uncontrolled mimicry, to a glassy stare, to a sociable facial expression |
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Progress of expressive (physiognomic) changes of a Down syndrome child |
Before
a) at 1 year of age |
During
b) at two years of age |
After
c)at four years of age |
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Highly stigmatized Down syndrome girl from a high Alpine valley who, at 2.5 years of age,
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was unable to speak; was restless, worrisome, and unmanageable |
six months after the beginning of treatment, the child already maintains eye contact and pays attention |
After four years of treatment – at 6 1/2 years of age, and after attending a normal kindergarten, the child speaks German and Italian, is enrolled in primary school on a trial basis. |
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Progress of a Down syndrome boy at: |
Before
1 1/1 years of age |
During
at three years of age |
After
at nine years of age |
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| Down syndrome boy with chronic infections |
at the beginning of treatment |
five months later |
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| Down syndrome boy with chronic infections |
Before
highly stigmatized facial expression |
After
considerable normalization of facial expression after five years of treatment |
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| Down syndrome girl at seven months of age before treatment |
Before
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After
after 4.5 years of treatment |
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| Photographs of a Down syndrome boy between two and seven years of age (a-f) from the family album |
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 Characteristic change of appearance, mimicry, and pigmentation, of four Down syndrome children under treatment from age two to eight |
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 Physiognomy and appearance (phenotype) of Down syndrome children treated from ages five to fourteen |
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 Facial expression and appearance of Down syndrome children under treatment since one year of age |
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 Representative cross-section of the appearance of treated Down syndrome boys from age four to fourteen |
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| BOY : Marcus |
Marcus as an infant |
Still unable to walk |
Marcus on the potty |
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Marcus and his younger sister. |
The siblings in a sleeping bag |
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| Play is hard work for the small boy. Marcus “works” with educational toys (coordinating, assigning). |
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